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This timing supports optimal absorption and provides antioxidant defense against daily environmental stressors

28 Excessive ROS production leads to an oxidative inactivation of anti-proteases, alveolar epithelium damage, increased neutrophil retention and increased expression of various inflammatory mediators in the pulmonary microcirculation, aggravating the development of COPD

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2 Lewandowski SA, Shaman JL

[DOI] [PMC free article] [PubMed] [Google Scholar] 256.Ahmed SF